10.2. SR 09-08-2015 - Laserfiche WebLink

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E-cigarettes: an evidence update 108 Participants attended the laboratory after overnight abstinence and used their EC under a standardised vaping regimen (10 puffs with a 30 second inter-puff interval) and then a 60 minutes period of ad lib vaping. The PK analyses showed a significant increase in plasma nicotine from baseline 2.0 ng/ml to 0.3 ng/ml within five minutes of the first puff. At the end of the ad-lib vaping period the maximum plasma nicotine concentration was 16.3 ng/ml. Dawkins and Corcoran (2014) examined nicotine delivery associated with the used of the Skycig 18 mg Crown tobacco bold cartridges in 14 vapers, who had been vaping for almost 5 months on average[6]. Using a similar methodology to Vansickel & Eissenberg (2012), the analysis of plasma nicotine from the seve n participants that provided a full blood set, showed that levels had increased from 0.74 to 6.77 ng/ml in 10 minutes. However there was individual variation (2.5 ng/ml to 13.4 ng/ml). After an hour of ad lib use the maximum nicotine concentration reached was 13.91 ng/ml, again with a wide range of levels observed between individuals (4.35 -25.6 ng/ml). Spindle et al., 2015 studied 13 experienced EC users (> 3 months, with the majority 9/13 using e-liquid strength of 24mg/ml and all using tank systems)[120]. Taking 10 puffs over 5 minutes resulted in an increase in mean blood nicotine levels from 2.4 ng/ml baseline to 19.2 ng/ml at 5 minutes. Practice in EC use also results in a modest increase in blood nicotine levels. Hajek et al., 2014 tested Greensmoke EC (a cigalike EC with 2.4% nicotine) in 40 smokers, naïve to EC[115]. Participants abstained from any nicotine use overnight and after a baseline blood sample was collected used the EC, ad lib, for 5 minutes. This procedure was undertaken twice, on first use and then again after 4 weeks of use. The maximum plasma concentrations increased from 4.6 ng/ml (range 0.9-9.0) to 5.7 ng/ml (range 1.9 - 11.0), although this increase was not significant. The area under the curve (AUC), however, did show a significant increase, from 96 (range 12-198) to 142 (range 56-234). The time to maximum plasma concentration (5 minutes) did not change. Nides et al., 2014 provided EC to participants (29 smokers, mean cigarette consumption of 20 cpd, and of 55% of whom had used EC in past) but also allowed them to practice using the EC (NJOY®King Bold, a cigalike EC, with 26mg nicotine) for a week prior to undertaking a PK analysis [116]. Participants (who abstained from all nicotine products for at least 12 hours) then were asked to use EC (10 puffs with a 30 second inter-puff interval) on two occasions 60 minutes apart. Pharmacokinetic (PK) analyses were undertaken in 16 participants who had no detectable plasma nicotine at baseline. The mean rise in blood nicotine was 3.5 ng/ml (range 0.8-8.5 ng/ml) at 5 minutes after the first round of puffing and 5.1 ng/ml (range 1.1 – 7.1 ng/ml) at 10 minutes after the second.