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E-cigarettes: an evidence update <br /> <br />65 <br />nicotine than cigarette exhalations [78]. Estimating environmental nicotine exposure, <br />however, has to take into account the fact that side -stream smoke (ie the smoke from <br />the lighted end of the cigarette, which is produced regardless of whethe r the smoker is <br />puffing or not) accounts for some 85% of passive smoking and there is no side-stream <br />EC vapour. A study measuring nicotine residue on surfaces in houses of smokers and <br />vapers reported only negligible levels from vaping, 169 times lower than from smoking <br />[79]. <br /> <br />Colard et al., 2015 describe a model for estimating environmental workplace exposure <br />[80]. The model predicts much lower nicotine exposure from vaping than from smoking, <br />at levels negligible in health terms. <br /> <br />Goniewicz and Lee 2014 found that nicotine from EC vapour gets deposited on <br />surfaces, but at very low levels [81]. This poses no concerns regarding exposure to <br />bystanders. At the highest concentration recorded (550 μg/m 2), an infant would need to <br />lick over 30 square metres of exposed surface to obtain 1mg of nicotine. <br /> <br />Ballbe et al., 2014 provide the most informative data collected to date as this study <br />measured the actual levels of airborne nicotine in homes of ex-smokers who live either <br />with smokers (N=25) or with vapers (N=5) and also in 24 control homes [82]. The study <br />also measured salivary and urinary cotinine in partners of smokers and vapers. As <br />expected, there was little nicotine in non-smokers’ homes. The air in the homes of <br />vapers contained six times less nicotine than the air in the homes of smokers. There <br />was less of a difference between cotinine levels of partners of vapers and smokers (1.4 <br />to 2 fold difference), most likely due to some ‘ex-smokers’ still occasionally smoking, but <br />even with this possible contamination, the nicotine levels absorbed via passive vaping <br />were negligible. Partners of vapers had mean cotinine concentrations of 0.19 ng/ml in <br />saliva and 1.75 ng/ml in urine, which is about 1,000 times less than the concentrations <br />seen in smokers and similar to levels generated by eating a tomato [83]. <br /> <br />Summary <br />EC release negligible levels of nicotine into ambient air with no identified health risks to <br />bystanders. <br /> <br />Nicotine in e-liquids <br />Fourteen studies tested more than 400 different e-liquids, mainly to check the accuracy <br />of product labelling. Their results are summarised in Table 6, updated from an earlier <br />review by Cheng et al., 2014 [84]. <br /> <br /> <br /> <br />