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E-cigarettes: an evidence update <br /> <br />50 <br />depending on the type and frequency of EC used at follow-up: compared to no EC use, <br />non-daily cigalike users were less likely to have quit smoking since baseline, daily <br />cigalike or non-daily tank users were no more or less likely to have quit, and daily tank <br />users were more likely to have quit. Overall, the two studies showed that daily use of <br />EC does not lead to lower cessation, and is associated with making quit attempts, <br />cigarette reduction, and if tank-type EC is used, is associated with smoking cessation. <br />Non-daily use of EC is not associated with quit-related outcomes, and may, if cigalike - <br />type EC are used, be associated with lower cessation. <br /> <br />Supporting these findings, using data from a longitudinal population study of smokers in <br />two metropolitan areas in the US, Biener et al., 2015 [44] measured use and intensity of <br />EC use at follow-up in a longitudinal sample of smokers at baseline from two US cities. <br />Biener also found that it was only intensive EC users (used daily for at least one month) <br />that were more likely to quit, less intensive EC users were no more likely to quit than <br />those not using EC. <br /> <br />There are limitations with these studies. For example, an unavoidable methodological <br />problem is that only people who currently smoke are included in these studies meaning <br />that smokers who switched completely to EC and stopped smoking are excluded. The <br />efficacy of EC is thus invariably underestimated. <br /> <br />A longitudinal telephone survey reported by Al-Delaimy et al., 2015 [50] among a <br />sample of 368 current smokers from California at baseline (2011) investigated the <br />relation between ‘ever have used’ versus ‘never will use’ EC, and making a quit attempt, <br />a 20% reduction in cigarettes per month, and quitting for more than one month at follow - <br />up (2012). Al-Delaimy included smokers at baseline who at both baseline and follow-up <br />reported the same EC status: never will use EC at both baseline and follow-up OR ever <br />have used EC at both baseline and follow-up, excluding anyone who gave different <br />responses. Also excluded were respondents who said they might use EC in the future at <br />baseline or follow-up, and respondents who had never heard of EC, reducing sample <br />size from n=980 to n=368. Al-Delaimy concluded that compared to smokers who <br />reported they never will use EC, respondents who had ever used EC were significantly <br />less likely to have reduced their cigarette consumption and quit at follow-up, with no <br />differences reported of quit attempts at follow-up. This study has serious methodological <br />problems that make its conclusions uninterpretable, first, the measure of EC use is ‘ever <br />use’, which could include even a puff on an EC and second, they applied several <br />exclusion criteria that are not clearly justified. <br /> <br />Studies of smokers enrolled in smoking cessation programs <br />Two recent studies have examined the use of EC among smokers enrolled in smoking <br />cessation programmes in longitudinal studies [51, 52]. Pearson et al., 2015 [51] <br />examined the relation between reporting using an EC for quitting at follow-up and