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13 <br />3.3 Seeing through controversy <br />Many points are made against e-cigarettes but they almost all suffer from flaws and can mislead <br />users about risks. Professor Robert West detailed six typical flaws (or ‘tactics’ if you believe this is <br />deliberate) in an editorial in the journal Addiction 50. <br />It is worth highlighting the ways in which science is being misused so that readers can be better placed to <br />evaluate the messages. <br />Failure to quantify: e.g., statement that e-cigarette vapour contains toxins so creating the impression that they are <br />dangerous as cigarettes, without indicating that the concentrations are typically orders of magnitude less than <br />tobacco smoke. <br />Failure to account for confounding and reverse causality: e.g., arguing that use of e-cigarettes reduces chances <br />of stopping because in cross-sectional surveys the prevalence of e-cigarette use is higher in smokers than in <br />recent ex-smokers. <br />Selective reporting: e.g., focusing on studies that appear to show harmful effects while ignoring those that do not. <br />Misrepresentation of outcome measures: e.g., claiming that e-cigarette use is prevalent among youth by using <br />data on the proportion who have ever tried and creating the misleading impression that they are all current e- <br />cigarette users. <br />Double standards in what is accepted as evidence: e.g., uncritically accepting conclusions from observational <br />studies with major limitations when these claim that electronic cigarettes are causing harm, but discounting <br />similar or better controlled studies when these appear to show the opposite. <br />Discrediting the source: e.g., arguing that researchers who have received financial support from e-cigarette <br />manufacturers (and even companies that do not manufacture e-cigarettes) are necessarily biased and their <br />results untrustworthy, and presenting themselves as having no conflicts of interest when their professional and <br />moral stance represents a substantial vested interest. <br />3.4 The case of snus – a cautionary tale <br />Many of the same ‘population’ arguments were made on a precautionary basis in the case to ban <br />‘oral tobacco’ in 1992 throughout the EU, even though it is 95-100% less hazardous than smoking. <br />On accession, Sweden was granted an exemption from the ban. In fact, this product is the reason <br />why Sweden has by far the lowest rate of smoking in the EU: 13% Swedish adults vs 28% EU <br />average 51. Snus has three main effects in Sweden and Norway: it is used to quit smoking; it is used to <br />substitute for smoking; it diverts young people from onset of smoking. It provides a compelling <br />‘proof of concept’ for tobacco harm reduction, and a warning about perverse impacts of regulation. <br />It also showed that tobacco control activists were prepared to mount a campaign against a product <br />that was achieved real reductions in disease and premature death. <br />3.5 Concern about the tobacco industry <br />A further source of critics’ concern is the possible negative role of the tobacco industry, which is <br />unsurprising given the history. In practice, and in the present, it is hard to see what this could be if <br />the e-cigarette industry remains competitive. The tobacco industry’s long-standing cigarette-based <br />business model is threatened by e-cigarettes. To survive the disruption they will need to enter the <br />market (as they are doing) and produce high quality attractive alternatives to smoking or risk losing <br />share in the recreational nicotine market to other tobacco or non-tobacco e-cigarette companies. It <br />is more likely that they will become important drivers of a wholesale switch from smoking to vaping <br /> <br />50 West R, Electronic cigarettes: getting the science right and communicating it accurately, Addiction, virtual edition on e- <br />cigarettes, December 2014. [link] <br />51 European Commission, Special Eurobarometer 385, Attitudes of European Citizens to Tobacco, March 2012